Universal dominant selectable marker cassette

Details Universal dominant selectable marker cassette Universal dominant selectable marker cassette

C - Chemistry, Metallurgy

12

N

195/39, 195/1.15

C12N 15/63 (2006.01) C07K 14/55 (2006.01) C12N 9/04 (2006.01) C12N 9/12 (2006.01) C12N 9/88 (2006.01) C12N 15/11 (2006.01) C12N 15/53 (2006.01) C12N 15/60 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01)

Patent

CA 1337716

A novel universal dominant selectable marker cassette is disclosed. The marker comprises the coding sequences for aminoglycoside phosphotransferase I (APH-I) which has been modified and truncated so as to render its use in recombinant vectors more convenient. The modified, truncated sequence (mtAPH-I) gene is capable, upon expression, of conferring resistance to a number of antibiotics on the host. One of these antibiotics, G418, is toxic to eucaryotic as well as procaryotic hosts. Also disclosed are methods of constructing fusion proteins having N-terminal sequences corresponding to a desired peptide sequence, and C-terminal sequences comprising the amino acids encoded by mtAPH-I.

475153

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