Universal site-specific nucleases

Details Universal site-specific nucleases Universal site-specific nucleases

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) C12N 9/22 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2108134

2108134 9222642 PCTABS00018 The present invention is directed to fusion proteins comprising ligand-protein hybrids. These hybrids can cleave any predetermined site within a DNA or RNA molecule, or hydrolyze a defined number of nucleotides from the DNA or RNA termini. In particular, the fusion proteins of the invention are composed of a ligand-exonuclease, or a ligand-endonuclease. Methods for using these fusion proteins are also encompassed in the present invention. Specifically, the present invention is directed to a Staphylococcal fusion protein.

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