C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/129, 530/7.0
C07K 14/445 (2006.01) A61K 39/015 (2006.01) C07K 7/08 (2006.01) A61K 39/00 (2006.01) F02B 75/02 (2006.01)
Patent
CA 1340472
The present invention relates to the use of a peptide from the circumsporozoite (CS) protein of Plasmodium falciparum (P. falciparum) and the derivatives thereof as a universally recognized T-cell epitope i.e. an epitope which is recognized in association with many different human and mouse major histocompatibility complex (MHC) haplotypes e.g. in the context of the human MHC class II molecules such as DRl, DR2, DR4, DR5, DRw6, DR7 or DR9. Furthermore the present invention relates to the above-mentioned peptide per se and to immunogenic compositions comprising such a peptide or a derivative thereof. These immunogenic compositions can be used as vaccines to elicit a durable immune response against a pathogenic agent in humans and animals irrespective of the MHC haplotype of the host.
599474
F. Hoffmann-La Roche & Co. Aktiengesellschaft
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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