Unlabelled and radioactive labelled derivatives of...

Details Unlabelled and radioactive labelled derivatives of... Unlabelled and radioactive labelled derivatives of...

A - Human Necessities

61

K

260/552, 260/515

A61K 35/16 (2006.01)

Patent

CA 1205089

ABSTRACT Unlabelled and radioactive labelled compounds of formula: Image wherein: i) R10 is GH, R11 is a radioisotope and R12 is 0; or ii) R10 is H, R11 is C1 and R12 is a radical of formula: Image wherein q is an integer from 1 to 3, and X1 is OH or a radical of formula: Image wherein R6 is a radiocative nuclide, R7 is hydroxyl and s is an integer from 1 to 4 are provided; the unlabelled compounds can be coupled with an immunogenic carrier to give an immunogen which can be used to raise antisera containing antibodies specific to the antidepressant bupropion; the labelled derivatives can be employed in a radioirnmunoassay for determining bupropion in biological fluids,

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