Unprotected amino aldehydes and applications for same

Details Unprotected amino aldehydes and applications for same Unprotected amino aldehydes and applications for same

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) C07D 203/08 (2006.01) C07D 487/22 (2006.01) C07K 1/00 (2006.01)

Patent

CA 2702605

The present invention relates to unprotected amino aldehydes and applications for same. More particularly, the present invention relates to novel aziridine aldehydes and processes for preparing these novel compounds. The invention also relates to aziridine-conjugated amino derivatives, and processes for preparing the same. Pentacyclic compounds may be prepared using the aziridine aldehydes of the present invention, and the invention relates to these compounds and the processes by which they are made. The invention also relates to aziridine-conjugated bioactive molecules, such as amino acids and peptides, and processes for preparing such compounds.

La présente invention concerne des aldéhydes aminés non protégés et leurs applications. L'invention concerne plus particulièrement de nouveaux aldéhydes aziridine ainsi que des procédés pour les préparer. L'invention concerne également des dérivés aminés à conjugaison Aziridine, ainsi que des procédés pour les préparer. Il est possible de préparer des composés pentacycliques à partir des aldéhydes aziridine de la présente invention, laquelle concerne également lesdits composés pentacycliques et les procédés permettant de les préparer. L'invention concerne en outre des molécules bioactives à conjugaison aziridine, par exemple des acides aminés et des peptides, ainsi que des procédés pour les préparer.

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