C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/25 (2006.01) A61K 31/13 (2006.01) A61K 31/451 (2006.01) C07C 211/40 (2006.01) C07D 295/033 (2006.01)
Patent
CA 2465738
Unsaturated 1-amino-alkylcyclohexane compounds which are systemically-active as NMDA, 5HT3 and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.
L'invention concerne: des composés 1-amino-alkylcyclohexane insaturés présentant une activité systémique en tant qu'antagonistes des récepteurs de NMDA, des récepteurs nicotiniques et des récepteurs 5HT¿3?; des compositions pharmaceutiques les contenant; leur procédé de préparation; un procédé de traitement des troubles du SNC impliquant des anomalies de transmission glutamatergique, sérotoninergique et nicotinique; un procédé de traitement de troubles immunomodulatoires, et de l'activité antimalarienne, antitrypanosomale, anti-virus de Borna, anti-HSV et anti-hépatite C.
Danysy Wojciech
Gold Markus
Henrich Markus
Jirgensons Aigars
Kalvinsh Ivars
Merz Pharma Gmbh & Co. Kgaa
Perley-Robertson Hill & Mcdougall Llp
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