Unsaturated hydroximic acid derivatives as parp inhibitors

Details Unsaturated hydroximic acid derivatives as parp inhibitors Unsaturated hydroximic acid derivatives as parp inhibitors

C - Chemistry, Metallurgy

07

D

C07D 295/088 (2006.01) A61K 31/15 (2006.01) A61K 31/155 (2006.01) A61K 31/40 (2006.01) A61K 31/4453 (2006.01) A61K 31/5375 (2006.01) C07C 251/58 (2006.01) C07D 207/06 (2006.01) C07D 213/54 (2006.01) C07D 217/04 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2342898

The object of the invention consists of novel unsaturated hydroximic acid derivatives, the process for their preparation and as active substance such as compounds containing pharmaceutical compositions. The novel compounds possess valuable pharmaceutical effects, so they can be used in the treatment of states connected with energy deficiency of the cell caused by PARP inhibition, in diabetes complications, in oxygen deficient status of the heart and brain, in neurodegenerative diseases, in the treatment of autoimmune and/or viral diseases. In formula (I).

Cette invention se rapporte à de nouveaux dérivés d'acide hydroximique insaturés, à un procédé servant à leur préparation, ainsi qu'à leur utilisation comme substance active, par exemple comme composés contenant des compositions pharmaceutiques. Ces nouveaux composés possèdent des effets pharmaceutiques valables, de telle sorte qu'ils peuvent servir dans le traitement d'états pathologiques associés à une déficience énergétique de la cellule, causée par l'inhibition de la PARP (poly(adénosine diphosphate ribose)polymérase), dans des complications du diabète, dans des situations de déficience en oxygène du coeur et du cerveau, dans les maladies neurodégénératives, ainsi que dans le traitement des maladies auto-immunes et/ou virales. Ces composés sont représentés par la formule (I).

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