Unsaturated hydroxyalkylquinoline acids as leukotriene...

Details Unsaturated hydroxyalkylquinoline acids as leukotriene... Unsaturated hydroxyalkylquinoline acids as leukotriene...

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01) A61K 31/47 (2006.01) C07D 215/12 (2006.01) C07D 215/18 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2053209

Compounds having the formula I: Image - i - are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

Les composés de formule I Image sont des antagonistes des leucotriènes et des inhibiteurs de la biosynthèse des leucotriènes. Ces composés servent d'agents anti-asthmatiques, anti-allergiques, anti-inflammatoires et cytoprotecteurs. Ils sont également utiles dans le traitement de l'angine de poitrine, du spasme vasculaire cérébral, de la néphrite glomérulaire, de l'hépatite, de l'endotoxémie, de l'uvéite et du rejet des allogreffes.

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