Unsaturated phosphonic acids and derivatives

Details Unsaturated phosphonic acids and derivatives Unsaturated phosphonic acids and derivatives

C - Chemistry, Metallurgy

07

F

167/225, 167/233

C07F 9/572 (2006.01) A61K 31/675 (2006.01) C07F 9/576 (2006.01) C07F 9/59 (2006.01) C07F 9/60 (2006.01)

Patent

CA 1312608

4-16190/+/CGC 1135 Unsaturated Phosphonic Acids and Derivatives Abstract of the Disclosure The present invention is concerned with the compounds of formula I, Image (I) wherein one or both of the acidic hydroxy groups of the phosphonic acid moiety may be etherified, m represents one or zero, R1 is carboxy, esterified carboxy or amidated carboxy, wherein the five-or six-membered heterocyclic ring may be additionally substituted on carbon and/or nitrogen, may have present a carbon-carbon double bond or may be fused on . adjacent carbon atoms with a six-membered carbocyclic ring, A represents lower alkenylene; and salts thereof. These compounds are useful for the treatment of nervous system disorders in mammals and as antagonists of the N-methyl-D-aspartate sensitive excitatory amino acid receptor.

552204

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