Upa/rag-2 mouse with mammalian repopulating hepatocytes for...

Details Upa/rag-2 mouse with mammalian repopulating hepatocytes for... Upa/rag-2 mouse with mammalian repopulating hepatocytes for...

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2343084

A method is provided for repopulating degenerated liver of immunotolerant mice which lack mature B and T lymphocytes with xenogenic mammalian hepatocytes, particularly primate hepatocytes to generate chimeric mice. In addition, a method of generating a human hepatitis virus-infected chimeric mouse is provided. A preferred xenogenic primate hepatocyte is derived from human, chimpanzee or baboon. These chimeric mice are useful in the investigation of host and viral mechanisms determining hepadnaviral persistence and hepatocarcinogenesis. Methods for monitoring the development of hepatitis and hepatocellular carcinoma as well as methods for testing and screening anti- viral and anti-cancer compounds with this model system are also provided.

L'invention concerne un procédé pour repeupler le foie dégénéré de souris immunotolérantes qui manquent de lymphocytes mûrs B et T avec des hépatocytes mammaliens xénogéniques, notamment avec des hépatocytes de primates, et ce afin de produire des souris chimères. En outre, l'invention concerne un procédé pour créer une souris chimère infectée par le virus de l'hépatite humain. De préférence, un hépatocyte xénogénique de primate est dérivé à partir de l'humain, du chimpanzé ou du babouin. Ces souris chimères sont utiles dans la recherche de mécanismes hôtes et viraux qui déterminent la persistance de virus ADN de l'hépatite et l'hépatocarcinogenèse. Enfin, l'invention concerne des procédés permettant de suivre l'évolution de l'hépatite et de l'hépatocarcinome ainsi que ceux destinés aux examens et au criblage de composés antiviraux et anticancéreux au moyen du système modèle de l'invention.

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