C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 17/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2283637
Peptides comprising the SRSRY sequence derived from the uPAR (urokinase receptor) are endowed with chemotactic activity, making them useful for preventing or activating the migration of cells in a mammal. More particularly, the peptides of the invention are useful for the treatment of cancer, autoimmune diseases and/or hyperinflammatory diseases and for stimulating wound healing.
L'invention concerne des peptides contenant la séquence SRSRY dérivée de l'uPAR (récepteur de l'urokinase). Ces peptides sont dotés d'une activité chimiotactique: ils peuvent ainsi utilement empêcher ou activer la migration de cellules chez un mammifère. Plus particulièrement, les peptides qui font l'objet de l'invention sont utiles pour le traitement du cancer, de maladies auto-immunes ou de maladies hyperinflammatoires ainsi que pour stimuler la guérison de blessures.
Blasi Francesco
Fazioli Francesca
Nicolai Sidenius
Resnati Massimo
Fondazione Centro San Raffaele Del Monte Tabor
Kirby Eades Gale Baker
Universita Degli Studi Di Milano
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