Ups as modifiers of the beta catenin pathway and methods of use

Details Ups as modifiers of the beta catenin pathway and methods of use Ups as modifiers of the beta catenin pathway and methods of use

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 14/435 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2535901

Human UP genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of UP are provided.

L'invention concerne des gènes humains d'uridine phosphorylase (UP) identifiés comme étant des modulateurs de la voie de la bêta caténine, et constituant donc des cibles thérapeutiques pour des troubles associés une fonction défectueuse de la bêta caténine. L'invention concerne également des procédés permettant d'identifier des modulateurs de la bêta caténine qui consistent à cribler des agents modulant l'activité de UP.

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