Uracil derivatives and production thereof

Details Uracil derivatives and production thereof Uracil derivatives and production thereof

C - Chemistry, Metallurgy

07

D

260/255, 260/245

C07D 239/22 (2006.01) C07C 273/18 (2006.01) C07D 239/553 (2006.01) C07D 239/557 (2006.01) C07F 7/18 (2006.01) C07C 275/20 (2006.01) C07C 275/50 (2006.01)

Patent

CA 1081226

Abstract of the disclosure New derivatives of the formula: Image (wherein X is O or NH; R1 is -OH or -SH which may optionally be etherified or esterified, or -NH2 which may optionally be substituted; R2 and R3, respectively, mean H, lower alkyl or Image ; and Y is an esterified or amidated carboxyl group, or CN). These derivatives are produced, by fluorination of corresponding 1,2,3,4- tetrahydro-2,4-dioxopyrimidine compounds and can be converted into 5-fluorouracil derivatives under hydrolytic conditions The new derivatives are able to prolong the lives of animals having carcinomas or have antiviral activity.

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