Uracil or thymine derivative for treating hepatitis c

Details Uracil or thymine derivative for treating hepatitis c Uracil or thymine derivative for treating hepatitis c

C - Chemistry, Metallurgy

07

D

C07D 239/22 (2006.01) A61K 31/513 (2006.01) A61P 31/12 (2006.01) C07D 239/54 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 409/10 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2699981

Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5- 6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t- butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)-yl)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.

La présente invention concerne les composés de formule I, qui sont utiles pour traiter les infections à l'hépatite C (VHC). Dans la structure des composés décrits, le dérivé d'uracile ou de thymine est relié via un phénylène à un système cyclique à deux cycles fusionnés (R6) ou en variante via un agent de liaison (L) supplémentaire à deux atomes à un monocycle ayant 5 à 6 éléments (R6). L'invention concerne également des polymorphes et des pseudopolymorphes de deux composés spécifiques : le N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)2-méthoxy-phényl)naphtalén-2-yl)méthanesulfonamide et le (E)-N-(4(3-t-butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1(2H)-yl)2-méthoxy-styryl-phényl)méthanesulfonamide.

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