Uracil reductase inactivators

Details Uracil reductase inactivators Uracil reductase inactivators

C - Chemistry, Metallurgy

07

D

C07D 239/54 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2092435

Uracil reductase inactivators, notably a 5-substituted uracil or. 5,6-dihydro - 5-substituted uracil, potentiate 5-fluorouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, iodo, cyano, halo-substituted C1-4 alkyl, C2-6 alkenyl, 1-halo- C2-6 alkenyl and halo-substituted C2-6 alkynyl.

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