Uracilic hydroquinone derivatives as type iv allergy inhibitors

Details Uracilic hydroquinone derivatives as type iv allergy inhibitors Uracilic hydroquinone derivatives as type iv allergy inhibitors

C - Chemistry, Metallurgy

07

D

C07D 405/02 (2006.01) A61K 31/505 (2006.01) C07D 239/545 (2006.01) C07D 311/58 (2006.01) C07D 401/02 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2216288

Disclosed is a hydroquinone derivative or a pharmaceutically acceptable salt thereof, the hydroquinone derivative being represented by formula (I): Image wherein R1 is a phenyl group which is unsubstituted or substituted with a substituent or substituents each independently selected from the group consisting of a halogen atom, a C1-4 alkyl group and a C1-4 alkoxy group; R2 is a hydrogen atom or a C1-4 alkyl group; each of R3 and R4 is independently a hydrogen atom or a C1-4 alkyl group; R5 is a hydrogen atom or a C1-4 alkyl group; each of R6, R7 and R8 is independently a hydrogen atom or a C1-4 alkyl group; P is a hydroxyl group; Q is a hydroxyl group, a C1-4 alkoxy group, a C1-18 acyloxy group or an oxo group; P may form together with Q an ether bond; R is a hydroxyl group, a C1-4 alkoxy group, a C1-18 acyloxy group or an oxo group, provided that when one of said Q and said R is an oxo group, the other is also an oxo group; 38 X is a single bond, an -NR10- group or a -CH2-NR10- group in which R10 is a hydrogen atom or a C1-4 alkyl group; Y is a methylene group or a carbonyl group; and dotted bonds in a six membered ring represent that said six membered ring has the maximum number of double bonds. The hydroquinone derivative or a pharmaceutically acceptable salt thereof according to the invention is useful as antiallergic agents. 39

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