C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4196 (2006.01) A61P 29/02 (2006.01) A61P 37/00 (2006.01) C07D 249/12 (2006.01)
Patent
CA 2447940
Urazole compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective as anti-inflammatory or immunosuppressive agents, wherein L and K are O or S; Q is a linker such as -O-, -S-, C(=O), and so forth, R1 is an aryl or heteroaryl group, and R3, R4a, R4c, Z, r, s and t are as defined in the specification.
Cette invention concerne des composés urazole représentés par la formule (I), ou bien des sels pharmaceutiquement acceptables, qui agissent efficacement comme agents anti-inflammatoires ou immunosuppresseurs. Dans cette formule, L et K sont O ou S; Q est un lieur tel que -O-, -S-, C(=O), etc., R?1¿ est un groupe aryle ou hétéroaryle, et R?3¿, R?4a¿, R?4c¿, Z, <i>r</i>, <i>s</i> et <i>t</i> sont conformes à la définition qui en est donnée dans le descriptif.
Dhar T. G. Murali
Iwanowicz Edwin J.
Launay Michele
Maillet Magali Jeannine Blandine
Nicolai Eric Antoine
Bristol-Myers Squibb Company
Cerep Sa
Gowling Lafleur Henderson Llp
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