Urea and urethane derivatives as integrin inhibitors

Details Urea and urethane derivatives as integrin inhibitors Urea and urethane derivatives as integrin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07D 235/30 (2006.01)

Patent

CA 2431974

Novel urea and urethane derivatives of general formula (I) in which R1~, R2~, R3~, R5~, R5'~, X, Y, B, m, n and o are as defined in Patent Claim 1, and physiologically acceptable salts or solvates thereof are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart disease, arteriosclerosis, inflammation, tumours. Osteoporosis, infections and restenosis after angioplasty or in pathological processes maintained or propagated by antiogenesis.

L'invention concerne des dérivés d'urée et d'uréthanne représentés par la formule générale (I), dans laquelle R<1>, R<2>, R<3>, R<5>, R<5'>, X, Y, B, m, n et o sont tels que définis au point 1 des revendications de brevet, y compris les sels ou solvates physiologiquement acceptables correspondants. Il s'agit d'inhibiteurs de l'intégrine susceptibles d'être utilisés pour soigner les maladies suivantes: thrombose, crise cardiaque, maladies coronariennes, artériosclérose, inflammation, tumeurs, ostéoporose, infections et resténose après angioplastie, ou bien processus pathologiques entretenus ou propagés par l'angiogenèse.

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