Urea-compounds active as vanilloid receptor antagonists for...

Details Urea-compounds active as vanilloid receptor antagonists for... Urea-compounds active as vanilloid receptor antagonists for...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4025 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2458632

Certain compounds of formula (I): or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein R1, R2, P, P', n, p, q, r and s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and composition for the treatment of disorders relating to the vanilloid receptor (VR1) such as pain, migraine, neuropathy, ischaemia, neurodegeneration, stroke, multiple sclerosis, asthma, inflammatory diseases.

La présente invention se rapporte à certains composés de la formule (I) ou à un sel pharmaceutiquement acceptable ou un solvate de ces derniers, dans laquelle R?1¿, R?2¿, P, P', n, p, q, r et s sont tels que définis dans la spécification, à un procédé de préparation de ces composés, à une composition pharmaceutique renfermant lesdits composés et à l'utilisation des composés et de la composition précités en médecine.

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