Urea compounds, their production and use

Details Urea compounds, their production and use Urea compounds, their production and use

C - Chemistry, Metallurgy

07

D

C07D 211/14 (2006.01) A61K 31/445 (2006.01) A61P 31/18 (2006.01) A61P 43/00 (2006.01) C07D 211/18 (2006.01)

Patent

CA 2386387

Compounds represented by general formula (I) or salts thereof which exhibit an excellent CCR5 antagonism and are useful as preventives and remedies for HIV infection of human peripheral blood mononuclear cells, in particular, AIDS, wherein R1 represents optionally substituted hydrocarbyl; R2 represents optionally substituted cyclic hydrocarbyl or an optionally substituted heterocycle; R3 represents halogeno, optionally substituted carbamoyl, optionally substituted sulfamoyl, sulfonate-origin acyl, optionally substituted C1-4 alkyl, optionally substituted C1-4 alkoxy, optionally substituted amino, nitro or cyano; R4 represents hydrogen or hydroxy; n is 0 or 1; and p is 0 or an integer of from 1 to 4.

On décrit des composés représentés par la formule (I) ou bien les sels de ces composés qui présentent un excellent antagonisme CCR5 et qui sont utiles en tant que substances prophylactiques et de traitement contre l'infection par le VIH des cellules mononucléaires du sang périphérique, en particulier le SIDA. Dans la formule (I), R?1¿ représente hydrocarbyle facultativement substitué; R?2¿ représente hydrocarbyle cyclique facultativement substitué ou un hétérocycle facultativement substitué; R?3¿ représente halogéno, carbamoyle facultativement substitué, sulfamoyle facultativement substitué, acyle issu de sulfonate, alkyle C¿1-4? facultativement substitué, alcoxy C¿1-4? facultativement substitué, amino facultativement substitué, nitro ou cyano; R?4¿ représente hydrogène ou hydroxy; n représente 0 ou 1;et p représente 0 ou un entier compris entre 1 et 4.

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