Urea-containing peptides as inhibitors of viral replication

Details Urea-containing peptides as inhibitors of viral replication Urea-containing peptides as inhibitors of viral replication

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 31/69 (2006.01) A61K 38/00 (2006.01) A61K 38/12 (2006.01) C07F 5/02 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2700383

The invention provides compounds urea-containing peptide compounds of Formula I and the pharmaceutically salts and hydrates thereof. The variables T, R1-R9, J, L, M, Y, Z, m, n, and t are defined herein. Certain compounds of Formula I are useful as antiviral agents. Certain urea-containing peptide compounds disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more urea containing peptides compounds and one or more pharmaceutically acceptable carriers, excipients, or diluents. Such pharmaceutical compositions may contain a urea containing peptides compound as the only active agent or may contain a combination of a urea containing peptides compound and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in mammals.

L'invention concerne des composés contenant des composés peptidiques contenant de l'urée de formule I et les sels et hydrates pharmaceutiquement acceptables de ceux-ci. Les variables T, R1-R9, J, L, M, Y, Z, m, n, et t sont définies ici. Certains composés de formule I sont utiles en tant qu'agents antiviraux. Certains composés peptidiques contenant de l'urée décrits ici sont des inhibiteurs puissants et/ou sélectifs de la réplication virale, en particulier, de la réplication du virus de l'hépatite C. L'invention concerne également des compositions pharmaceutiques contenant un ou plusieurs composés peptidiques contenant de l'urée et un ou plusieurs véhicules, excipients ou diluants pharmaceutiquement acceptables. Ces compositions pharmaceutiques peuvent contenir un composé peptidique en tant qu'agent actif unique ou peuvent contenir une combinaison d'un composé peptidique contenant de l'urée et un ou plusieurs autres agents pharmaceutiquement actifs. L'invention concerne également des procédés de traitement d'infections virales comprenant des infections à l'hépatite C chez des mammifères.

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