Urea derivatives as hiv aspartyl protease inhibitors

Details Urea derivatives as hiv aspartyl protease inhibitors Urea derivatives as hiv aspartyl protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 333/02 (2006.01) A61K 31/357 (2006.01) A61K 31/381 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) C07C 273/02 (2006.01) C07C 311/19 (2006.01) C07C 335/12 (2006.01) C07C 335/14 (2006.01) C07D 209/16 (2006.01) C07D 213/02 (2006.01) C07D 213/40 (2006.01) C07D 213/75 (2006.01) C07D 213/81 (2006.01) C07D 217/12 (2006.01) C07D 217/22 (2006.01) C07D 295/02 (2006.01) C07D 317/46 (2006.01) C07D 317/58 (2006.01) C07D 319/16 (2006.01) C07D 319/18 (2006.01) C07D 333/20 (2006.01)

Patent

CA 2374362

The present invention provides HIV aspartyl protease inhibitors of the formula; (see fig I) and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, Y is O, S, NH or N-CN, wherein Cx may be, for example COOH, or CHZOH, wherein R1 is selected from the group consisting of a benzenesulfonyl group of formula II as defined herein, wherein R2 may be, for example, iso- butyl, or 3-methylbutyl, and wherein R3 and R4 are as defined herein.

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