Urea derivatives as vr1- antagonists

Details Urea derivatives as vr1- antagonists Urea derivatives as vr1- antagonists

C - Chemistry, Metallurgy

07

C

C07C 275/24 (2006.01) A61K 31/17 (2006.01) C07C 275/26 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 275/32 (2006.01) C07C 275/40 (2006.01) C07C 275/42 (2006.01) C07C 323/43 (2006.01) C07D 209/44 (2006.01) C07D 209/88 (2006.01) C07D 213/40 (2006.01) C07D 213/75 (2006.01) C07D 217/06 (2006.01) C07D 223/16 (2006.01) C07D 231/56 (2006.01) C07D 295/135 (2006.01) C07D 307/52 (2006.01) C07D 317/06 (2006.01) C07D 317/58 (2006.01) C07D 333/20 (2006.01) C07D 333/36 (2006.01)

Patent

CA 2469967

This invention relates to urea derivatives of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof: (I) wherein Y is R1- R6 and X have the same meanings given in the description, which is useful as an active ingredient of pharmaceutical preparations. The urea derivatives of the present invention has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.

L'invention concerne des dérivés d'urée et des sels de ceux-ci utiles en tant qu'ingrédient actif de préparations pharmaceutiques. Les dérivés d'urée de cette invention possèdent une excellente activité en tant qu'antagoniste de VR1 et sont utiles dans la prophylaxie et le traitement de maladies associées à l'activité de VR1, plus spécifiquement dans le traitement de l'incontinence urinaire insistante, hyperactivité de la vessie, douleur chronique, douleur neuropathique, douleur postopératoire, douleur arthritique rhumatoïde, névralgie, neuropathies, algésie, blessure des nerfs, ischémie, maladie neurodégénérative, accident vasculaire cérébral, incontinence et/ou troubles inflammatoires.

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