C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/26 (2006.01) A61K 31/55 (2006.01) A61P 3/00 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 471/04 (2006.01) C07D 471/08 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 498/08 (2006.01)
Patent
CA 2711757
The present invention relates to compounds defined by formula (I) wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 .beta.-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
La présente invention concerne des composés répondant à la formule (I), dans laquelle les groupes A, B, X, m, n et o sont tels que définis dans la revendication 1. Les composés présentent une activité pharmacologique très utile et sont, en particulier, des inhibiteurs de la 11 ß-hydroxystéroïde déshydrogénase (HSD) de type 1. Ils sont donc appropriés pour le traitement et la prévention de maladies susceptibles dêtre influencées par linhibition de cette enzyme, telles que des maladies métaboliques, en particulier le diabète de type 2, lobésité et la dyslipidémie.
Eckhardt Matthias
Hamilton Bradford
Himmelsbach Frank
Peters Stefan
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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