C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/02 (2006.01) A61K 31/46 (2006.01) A61P 3/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2738453
The present invention relates to compounds defined by formula I wherein the groups R1, Y1 to Y4, V, W, and X are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 .beta.-hydroxys-teroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibi-tion of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
La présente invention concerne des composés définis par la formule I dans laquelle les groupes R1, Y1 à Y4, V, W, et X sont définis comme décrit dans la revendication 1, possédant une activité pharmacologique intéressante. En particulier, les composés sont des inhibiteurs de 11-ß-hydroxystéroïde déshydrogénase (HSD) 1 et sont donc adaptés pour le traitement et la prévention de maladies qui peuvent être influencées par linhibition de cette enzyme, telles que des maladies métaboliques, en particulier le diabète de type 2, lobésité, et la dyslipidémie.
Eckhardt Matthias
Hamilton Bradford S.
Himmelsbach Frank
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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