C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/81 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07D 209/14 (2006.01) C07D 209/20 (2006.01) C07D 333/58 (2006.01) C07D 333/60 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2068261
ABSTRACT OF THE DISCLOSURE The disclosure describes compounds of the formula: Image (I) wherein R1 is aryl which may be substituted with halogen, nitro, amino, lower alkylamino, lower alkoxy or acylamino, R2 is hydrogen; alkyl; cycloalkyl; or lower alkyl which is substituted with cyclo(lower)alkyl, cyclo(lower)alkenyl, a hetero- cyclic group or aryl optionally substituted with substituent(s) selected from the group consisting of halogen, hydroxy and lower alkoxy, R3 is hydrogen, lower alkyl or aryl which may be substituted with halogen, nitro, amino or lower alkylamino, R4 is hydrogen, halogen, lower alkyl, lower alkoxy or aryl which may be substituted with halogen, R5 is hydrogen, halogen, lower alkyl or aryl, A is a single bond or lower alkylene, and X is O, S or NH, provided that R3 is aryl which may be substituted with halogen, nitro, amino or lower alkylamino, or R4 is halogen, lower alkoxy or aryl which may be substituted with halogen, when R2 is cycloalkyl, and pharmaceutically acceptable salts thereof. The preparation of these compounds, pharmaceutical compositions containing them and their use as a medicament for treating hypochloles- terolemia, hyperlipidemia, atherosclerosis or diseases caused thereby are also disclosed.
Itoh Yoshikuni
Ohne Kazuhiko
Tanaka Hirokazu
Fujisawa Pharmaceutical Co. Ltd.
Swabey Ogilvy Renault
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