Urea derivatives useful as calcium receptor modulators

Details Urea derivatives useful as calcium receptor modulators Urea derivatives useful as calcium receptor modulators

A - Human Necessities

61

K

A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) C07D 213/38 (2006.01) C07D 213/75 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 217/22 (2006.01) C07D 231/52 (2006.01) C07D 231/56 (2006.01) C07D 235/14 (2006.01) C07D 235/30 (2006.01) C07D 239/46 (2006.01) C07D 257/04 (2006.01) C07D 261/08 (2006.01) C07D 261/20 (2006.01)

Patent

CA 2630860

The present invention provides compounds of formula (I): in which Y is oxygen or sulphur; R1 and R~1 are optionally substituted aryl, heteroaryl or a fused ring structure, R2 and R'2 are each H, or optionally substituted alkyl, alkylaminoalkyl or dialkylaminoalkyl, or R2 and R'2 and their N form a saturated or unsaturated optionally substituted heterocycle, R3 represents a group of formula -(CH2)P-Ar-Rn, wherein p is 0 or 1 and, when p is 1, is optionally substituted, Ar is aryl or heteroaryl, and each R is H, halogen; hydroxyl; trifiuoromethyl; linear and branched alkyl, alkenyl, alkynyl, and alkoxyl groups, all optionally further substituted by one or more of hydroxy groups, halogen atoms, alkoxy groups, amino groups, and alkylthio groups; linear and branched alkoxyl groups; linear and branched thioalkyl groups; aryl groups; aralkyl groups; aralkoxy groups; aryloxy groups; perfluoroalkyl; -CN; - NR4R5, -C(=X)NR4R5,-O-C(=X)NR4R5, -SO2NR4R5, - Alk-NR4R5, -NZC(=X)(NH)qR6, - Alk-NZC(=X)(NH)qR6, -C(=X)R6, -Alk-C(=X)(NH)qR6, -NHSO2R7, -SO2R7, -SOR7, - SR7, or is a saturated or unsaturated heterocyclyl group, and salts and esters thereof, are useful in the treatment of conditions susceptible to modulating ion channels, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

La présente invention concerne des composés de formule (I) : dans laquelle Y est un oxygène ou un soufre ; R1 et R\ sont chacun un aryle, ou hétéroaryle éventuellement substitué ou une structure cyclique fusionnée, R2 et R'2 sont chacun H ou un alkyle, alkylaminoalkyle ou dialkylaminoalkyle éventuellement substitué ou bien R2 et R'2 et leurs N forment un hétérocycle saturé ou insaturé éventuellement substitué, R3 représente un groupe de formule -(CH2)p-Ar-Rn, p valant 0 ou 1 et le groupe étant éventuellement substitué lorsque p vaut 1, Ar étant un aryle ou un hétéroaryle et chaque R étant H ou un halogène ; un hydroxyle ; un trifulorométhyle ; des groupes alkyle, alcényle, alcynyle et alcoxy linéaires et ramifiés, tous étant éventuellement en plus substitués par un ou plusieurs groupes hydroxy, atomes d'halogène, groupes alcoxy, groupes amino et groupes alkylthio ; des groupes alcoxy linéaires et ramifiés ; des groupes thioalkyle linéaires et ramifiés ; des groupes aryle ; des groupes aralkyle ; des groupes aralcoxy ; des groupes aryloxy ; un perfluoroalkyle.

Affiliated with

Also associated with

Rating

Urea derivatives useful as calcium receptor modulators does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Urea derivatives useful as calcium receptor modulators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Urea derivatives useful as calcium receptor modulators will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1842726