Urea derivatives useful in the treatment of heart failure

Details Urea derivatives useful in the treatment of heart failure Urea derivatives useful in the treatment of heart failure

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/44 (2006.01) A61K 31/4545 (2006.01) A61P 9/00 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2511970

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

La présente invention a trait à certains dérivés substitués de l'urée permettant la modulation sélective du sarcomère cardiaque, par exemple par la potentialisation de la myosine cardiaque, et utiles dans le traitement de l'insuffisance cardiaque systolique y compris l'insuffisance cardiaque globale.

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