Urea inhibitors of map kinases

Details Urea inhibitors of map kinases Urea inhibitors of map kinases

C - Chemistry, Metallurgy

07

D

C07D 403/02 (2006.01) A61K 31/381 (2006.01) A61K 31/4155 (2006.01) A61K 31/445 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 403/14 (2006.01) C07D 405/02 (2006.01) C07D 405/14 (2006.01) C07D 407/02 (2006.01) C07D 407/14 (2006.01) C07D 411/02 (2006.01) C07D 411/14 (2006.01) C07D 413/02 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2589271

The present invention is directed to a compound having the formula (I) wherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP Kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.

Composé de formule (I) dans laquelle R1, R2, G et Q sont définis dans le descriptif. Lesdits composés sont utiles en tant qu'inhibiteurs de protéine kinases telles que les MAP kinases, en particulier les p38 kinases. La présente invention concerne également des compositions contenant un composé de formule ci-dessus. Les composés et compositions décrits sont utiles pour traiter et prévenir des états ou maladies inflammatoires. La présente invention concerne en outre une méthode de traitement ou de prévention d'un état pathologique à médiation par les protéine kinases.

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