Urea/lactate topical compositions for dry skin

Details Urea/lactate topical compositions for dry skin Urea/lactate topical compositions for dry skin

A - Human Necessities

61

K

A61K 31/17 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2104733

Methods and compositions for the treatment of dry skin involve the topical application to affected sites of a composition comprising from about 1% to about 12% by weight of urea and from about 1% to about 10% by weight of and alkali or an earth metal salt of lactic acid such as sodium, potassium or calcium lactate or a mixture of these salts in water-in-oil emulsions. In lotion embodiments, the emulsion typically contains from about 1% to about 10% by weight, more narrowly from about 2% to about 5% by weight, lactate and from about 1% to about 10% by weight, more narrowly from about 2% to about 5% by weight, urea. In cream embodiments, the emulsion typically contains from about 1% to about 5% by weight, more narrowly from about 2% to about 4% by weight, lactate, and from about 3% to about 15% by weight, more narrowly from about 5% to about 10% by weight, urea. Application of the compositions of the invention to the skin controls transepidermal water loss and minimizes disturbance of the epidermal barrier layer.

Méthodes et compositions destinées au traitement de la peau sèche. Elles comprennent l'application topique, aux endroits touchés, d'une composition constituée d'environ 1 à 12 % en poids d'urée et d'environ 1 à 10 % en poids d'un sel métallique alcalin ou ferreux d'acide lactique comme le sodium, le potassium, le lactate de calcium ou un mélange de ces sels dans des émulsions huileuses. En ce qui touche les lotions, l'émulsion contient généralement 1 à 10 % en poids, plus précisément 2 à 5 % en poids, de lactate et environ 1 à 10 % en poids, plus précisément 2 à 5 % en poids, d'urée. Pour ce qui est des crèmes, l'émulsion contient généralement 1 à 5 % en poids, plus précisément 2 à 4 % en poids, de lactate et 3 à 15 % en poids, plus précisément 5 à 10 % en poids, d'urée. L'application de ces compositions sur la peau permet de réduire la perte d'eau transépidermique et les perturbations au niveau de la barrière épidermique.

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