Urea stabilized with a lactone in various pharmaceutical and...

Details Urea stabilized with a lactone in various pharmaceutical and... Urea stabilized with a lactone in various pharmaceutical and...

A - Human Necessities

61

K

167/242, 167/243

A61K 31/365 (2006.01)

Patent

CA 1288353

ABSTRACT OF THE DISCLOSURE A pharmaceutical preparation containing 1 to 50% urea and 0.05 to 30% of a lactone is disclosed. A preferred lactone is gamma-butyrolactone which is preferably present in an amount of about 0.05 to 0.1 part by weight per 1 part by weight of urea. The lactone stabilizes the urea with respect to various parameters including changes in pH. The pharmaceutical preparation may be any preparation with stabilized urea such as a skin lotion or cream used to moisturize skin, or a post surgical preparation because urea aids in debridement, dissolves coagulum and promotes epithelialization. alternatively the preparation may be an injectable solution used in the treatment for mobilization of edema fluid, as urea is used for an osmotic diuretic.

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