Ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 207/34 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) C07D 401/14 (2006.01) C07H 13/00 (2006.01)

Patent

CA 2050331

The invention relates to ureido derivatives of substituted pyrroles of formula (I) wherein each of m and n, being the same, is an integer of 1 to 3; W is oxygen of sulphur; each of the B groups, which are the same, is a) a saturated or unsaturated, carbo- cyclic or condensed carbocylic ring substituted by one or more acid groups; b) a saturated or unsaturated, heteromonocyclic or heterobicyclic ring, containing one or more heteroatoms chosen from nitrogen, oxygen and sulphur, substituted by one or more acid groups; c) a pyranyl or furanyl sugar residue substituted by one or more acid groups; or d) a -CH2(CHA) r CH2A group, wherein each A group, being the same or different, is an acid group and r is 0, 1 or 2; and the pharmaceutically acceptable salts thereof, which are useful as angiogenesis inhibitors.

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