Urethane-protected amino acid-n-carboxyanhydrides

Details Urethane-protected amino acid-n-carboxyanhydrides Urethane-protected amino acid-n-carboxyanhydrides

C - Chemistry, Metallurgy

07

D

260/304, 530/1.0

C07D 211/60 (2006.01) C07D 263/26 (2006.01) C07D 263/44 (2006.01) C07D 277/04 (2006.01) C07D 277/34 (2006.01) C07D 413/12 (2006.01) C07K 1/00 (2006.01) C07K 1/02 (2006.01) C07K 1/04 (2006.01)

Patent

CA 1321280

1027-2 ABSTRACT OF THE DISCLOSURE A urethane-protected amino acid-N-carboxyanhydride or N-thiocarboxyanhydride having the structure: Image wherein R and R' are hydrogen, alkyl, cycloalkyl, substituted alkyl substituted cycloalkyl, aryl, or substituted aryl and at least one of R and R' is other than hydrogen; R" is alkyl, aryl, substituted alkyl or substituted aryl; Z is oxygen or sulfur; and n is 0, 1, or 2. These compounds find use in polypeptide synthesis.

592823

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