Urethanes and ureas that induce cytokine production

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 5/068 (2006.01) A61K 31/195 (2006.01) A61K 31/27 (2006.01) A61K 38/05 (2006.01) C07C 271/22 (2006.01) C07C 275/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2123261

Title: URETHANES AND UREAS THAT INDUCE CYTOKINE PRODUCTION Abstract The invention relates to novel ureas and urethanes of Formula I: Image Formula 1 which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infec- tious diseases, and in the enhancement of immune re- sponse.

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