Uridine derivatives as antibiotics

Details Uridine derivatives as antibiotics Uridine derivatives as antibiotics

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) A61K 31/70 (2006.01) A61P 31/04 (2006.01) C07H 15/18 (2006.01)

Patent

CA 2408453

The invention concerns compounds of formula (I) wherein: R¿2? is hydrogen, halogen, alkyl, alkenyl or alkynyl, a OH, O-alkyl, OCO-alkyl radical, an O-aryl or OCO-aryl radical; R¿4? is CH¿2?NH¿2?; CH¿2?NHalkyl, CH¿2?N (alkyl1) (alkyl2), CH¿2?-guanidine, CH¿2?-amidine optionally substituted; R¿5? represents in particular (a) or (b) or (c) or (d), a CH¿2?N¿3? radical (e); R¿8? is hydrogen or alkyl; R¿9? is alkyl, aryl or heteroaryl, R¿8? and R¿9? capable of forming a heterocycle, or R¿5? represents a CH¿2?alkyl, CH¿2?Oalkyl or CO¿2?alkyl, CH¿2?Salkyl radical; R¿6? is hydrogen or halogen, OH, Oalkyl, OCOalkyl, S-alkyl or S-aryl; R¿7? is hydrogen or OH. The compounds of formula (I) exhibit antibiotic properties.

Les composés de formule (I), R2 hydrogène, halogène, alkyle, alkényle ou alkynyle, un radical OH, O-alkyle, OCO-alkyle, un radical O-aryle ou OCO- aryle, R4 CH2NH2, CH2NHalkyle, CH2N (alkyle1) (alkyle2), CH2-guanidine, CH2- amidine éventuellement substitué, R5 représente notamment (a) ou (b), (c) ou (d), un radical CH2N3 (e), R8 hydrogène ou alkyle, R9 alkyle, aryle ou hétéroaryle, R8 et R9 pouvant constituer un hétérocycle, ou R5 représente un radical CH2akyle, CH2Oalkyle ou CO2alkyle, CH2S alkyle, R6 hydrogène ou halogène, OH, Oalkyle, OCOalkyle, S-alkyle ou S-aryle, R7 hydrogène ou OH. Les composés de formule (I) présentent des propriétés antibiotiques.

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