C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/38 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) C07K 16/18 (2006.01) C40B 30/00 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2748937
Use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precur-sor alpha-2-HS-glycoprotein, urine alpha- 1 antitrypsin, urine alpha- 1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.
L'invention porte sur l'utilisation de biomarqueurs urinaires et sériques dans le diagnostic d'une néphropathie diabétique, la stadification d'une néphropathie diabétique, la surveillance de la progression d'une néphropathie diabétique et l'évaluation de l'efficacité de traitements contre une néphropathie diabétique. Ces biomarqueurs comprennent l'alpha-2-HS-glycoprotéine précurseur urinaire, l'alpha-1-antitrypsine urinaire, l'alpha-1-glycoprotéine acide urinaire, l'ostéopontine urinaire, l'ostéopontine sérique, leurs fragments et leurs associations.
Chen Jin-Shuen
Chen Yi-Ting
Cheng Ping-Fu
Hsu Tsai-Wei
Li Hung-Yi
Gowling Lafleur Henderson Llp
Industrial Technology & Research Institute
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