Urogenital or anorectal transmucosal vaccine delivery system

Details Urogenital or anorectal transmucosal vaccine delivery system Urogenital or anorectal transmucosal vaccine delivery system

A - Human Necessities

61

K

A61K 9/02 (2006.01) A61K 9/00 (2006.01) A61K 39/116 (2006.01)

Patent

CA 2401804

The invention is directed to a suppository based vaccine delivery system for immunizing against urogenital and anorectally transmitted infectious disease in humans and animals and a method for treating the same. More particularly, this invention is directed to a suppository based vaccine delivery system for the prophylaxis against or treatment of urogenital or anorectal transmitted infectious diseases, such as from viral or microbial pathogens. The suppository based delivery system comprises vaccine and/or vaccine adjuvant(s) comprised of whole or fractionated viral or other microbial pathogens, or their purified cellular constituents, whether native, mutated, synthetic, cloned or recombinantly expressed, that consists of nucleic acids, proteins, lipids or other antigenic determinants capable of producing humoral or cellular-mediated immunity in humans or animals; and a polyethylene glycol base; wherein the suppository is adapted to be inserted into a bodily orifice of a human or animal so as to allow the suppository to be in contact with tissue of the bodily orifice to facilitate transfer of vaccine or vaccine adjuvant(s) material therethrough.

L'invention concerne un système d'administration de vaccin à base de suppositoires permettant d'immuniser contre les maladies infectieuses transmissibles par voie urogénitale et ano-rectale chez l'homme et l'animal, ainsi qu'une méthode de traitement correspondante. L'invention concerne plus particulièrement un système d'administration de vaccin par suppositoires destiné à la prophylaxie ou au traitement des maladies infectieuses transmissibles par voie urogénitale et ano-rectale, notamment par des agents pathogènes viraux ou microbiens. Ce système d'administration de vaccin et/ou d'adjuvants de vaccins constitués d'agents pathogènes viraux ou autres microbiens, entiers ou fractionnés, ou de leurs constituants cellulaires purifiés, soient-ils natifs, mutants, synthétiques, clonés ou exprimés de manière recombinante, constitués d'acides nucléiques, de protéines, de lipides ou d'autres déterminants antigéniques pouvant produire une immunité cellulaire ou humorale chez l'homme ou l'animal ; ainsi qu'une base de polyéthylène glycol, le suppositoire étant conçu pour être inséré dans un orifice corporel chez l'homme ou chez l'animal, de manière à être en contact avec le tissu dudit orifice afin de favoriser le transfert du vaccin ou des adjuvants de vaccins à travers ce dernier.

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