Urokinase precursor-stabilizing method and dried composition

C - Chemistry – Metallurgy – 12 – N

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C12N 9/96 (2006.01) C12N 9/72 (2006.01)

Patent

CA 2014009

ABSTRACT A method for stabilizing urokinase precursors which comprises adding at least one species of stabilizer selected from the polar amino acids and salts thereof to an urokinase precursor and a dried urokinase precursor composition which comprises an urokinase precursor as the main ingredient and at least one species selected from the polar amino acids and salts thereof as the stabilizing agent are disclosed. Accor- ding to the present invention, the urokinase precursors can be stabilized even under the conditions in which the uroki- nase precursors may be inactivated, such as purification, formulation, lyophilization and storage periods for the uro- kinase precursors.

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