Urokinase-type plasminogen activator receptor epitope,...

Details Urokinase-type plasminogen activator receptor epitope,... Urokinase-type plasminogen activator receptor epitope,...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) C07K 14/745 (2006.01) C12N 9/72 (2006.01)

Patent

CA 2671971

The present invention relates to antibodies, and antigen-binding fragments thereof, specific for urokinase-type plasminogen activator receptor (uPAR) and uses thereof for the treatment or prevention of cancer. In particular, the antibodies of the invention are specific for a particular epitope on uPAR. These antibodies interfere with uPAR signaling. Such antibodies are used in diagnostic and therapeutic methods, particularly against cancer.

L'invention concerne des anticorps dont des fragments se lient à un antigène et qui sont spécifiques au récepteur des activateurs du plasminogène de type urokinase (uPAR) ainsi que leurs utilisations dans le traitement ou la prévention du cancer. En particulier, les anticorps selon l'invention sont spécifiques à un épitope particulier présent sur uPAR. Ces anticorps interfèrent avec la signalisation d'uPAR. De tels anticorps sont utilisés dans des procédés thérapeutiques et diagnostiques, en particulier contre le cancer.

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