Urotensin ii receptor antagonists

Details Urotensin ii receptor antagonists Urotensin ii receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01)

Patent

CA 2684147

Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6 W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.

L'invention concerne des composés de formule (I), R1, R2, R3, R4, R5, R6, W et Y étant tels que décrits, ou un tautomère, un promédicament, un solvat ou un sel de ceux-ci. Ces composés s'utilisent comme inhibiteurs de l'urotensine II et s'utilisent donc pour le traitement d'une variété de maladies et de troubles qui sont provoqués ou entretenus par l'interaction de l'urotensine II avec son récepteur, ce qui inclut des maladies cardiovasculaires. Cette invention concerne également des compositions pharmaceutiques comportant ces composés, les procédés d'utilisation de ces composés dans le traitement de divers troubles et maladies, des procédés pour préparer ces composés et des produits intermédiaires utiles dans ces procédés.

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