Urotensin peptides

Details Urotensin peptides Urotensin peptides

C - Chemistry, Metallurgy

07

K

530/7.1

C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1243302

UROTENSIN PEPTIDES ABSTRACT OF THE DISCLOSURE UI (Urotensin I) or carp urotensin, obtained from Cyprinus carpio, has the formula: H-Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His- Leu-Leu-Arg-Asn-Met-Ile-Glu-Met-Ala-Arg-Asn-Glu-Asn-Gln- Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu-Asp-Glu-Val- NH2. UI or a biologically active fragment thereof or a pharmaceutically acceptable salt of either, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals to achieve a substantial elevation of ACTH, .beta.-endorphin, .beta.-lipotropin and corticosterone levels and/or a lowering of systemic blood pressure over an extended period of time.

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