Urotensins ii of mammals and their uses

Details Urotensins ii of mammals and their uses Urotensins ii of mammals and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/22 (2006.01) C07K 14/575 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2352606

The invention concerns peptides of mammals having a urotensin II (UII) structure, and their uses as medicines, in particular in the form of a composition for treating neurodegenerative diseases or traumatism of the spinal cord. Said polypeptides comprise at their C-terminal end a heptapeptide with the following sequence: Cys-Phe-Trp-Lys-Tyr-Cys-Xaa wherein Xaa represents Val or Ile characterised in that they belong to the family of urotensin II and they have at least 45 %, and preferably at least 70 % similarity with the polypeptide of sequence SEQ ID N?O¿:1, corresponding to the human prepro-urotensin II. The invention also concerns nucleic acid sequences coding for said polypeptides, oligonucleotides included in said sequences, and the use of said sequences as primers and probes and for expressing urotensin II of mammals. The invention also concerns the use of said polypeptides for selecting hypertension activity antagonists.

Peptides de mammifères présentant une structure de type urotensine II (UII), ainsi que leurs applications en tant que médicament, notamment sous la forme d'une composition destinée au traitement des maladies neurodégénératives ou des traumatismes de la moelle épinière. Lesdits polypeptides comprennent à leur extrémité C-terminale un heptapeptide présentant la séquence suivante: Cys-Phe-Trp-Lys-Tyr-Cys-Xaa dans laquelle Xaa représente Val ou Ile, en ce qu'ils appartiennent à la famille des urotensines II et en ce qu'ils présentent au moins 45 %, et de préférence au moins 70 % de similarité avec le polypeptide de séquence SEQ ID NO:1, correspondant à la prépro-urotensine II humaine. Séquences d'acides nucléiques codant pour lesdits polypeptides, oligonucléotides compris dans lesdites séquences, et utilisation desdites séquences comme amorces et comme sondes et pour l'expression des urotensines II de mammifères. Utilisation desdits polypeptides pour la sélection d'anti- hypertenseurs.

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