A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/32 (2006.01) A61K 9/00 (2006.01) A61K 31/085 (2006.01)
Patent
CA 2201872
The present invention provides a composition and use of a composition comprising a bioadhesive cross-linked polycarboxylic acid polymer formulation that enables the use of relatively low amounts of anti-STD agents such as N-9, to be used to prevent infection by STDs without causing the irritation to genital tissue that often accompanies higher doses of anti-STDs. The bioadhesive polymer maintains greater contact between the anti-STD agent and the infectant for a much greater period of time, enabling a lower concentration to act longer on the infectant, when compared to currently- available commercial applications containing N-9. Such delivery will enable a safe and non-irritating decrease in the risk of infection with STDs, including HIV.
La présente invention se rapporte à une composition comprenant une formulation de polymère d'acide polycarboxylique réticulé et bio-adhésif, ainsi qu'à l'utilisation de cette composition, laquelle permet d'utiliser des doses relativement faibles d'agents agissant contre les maladies sexuellement transmissibles (MST), tels que N-9, pour prévenir de telles maladies sans entraîner les irritations des tissus génitaux qui accompagnent fréquemment l'application de doses plus élevées des agents anti-MST. Le polymère bio-adhésif permet de maintenir un contact considérablement prolongé et plus important entre l'agent anti-MST et l'agent infectieux, ce qui permet à l'agent anti-MST d'agir plus longuement, et en une plus faible concentration, contre l'agent infectieux, par opposition aux formulations commerciales contenant du N-9 actuellement disponibles. Un tel système d'apport permettra de réduire de manière sûre, et sans irritations, le risque d'infection par les MST, y compris le VIH.
Bologna William Joseph
Levine Howard Leslie
Columbia Laboratories Inc.
Columbia Laboratories (bermuda) Limited
Mccarthy Tetrault Llp
LandOfFree
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