Use of 17-ketosteroid compounds and derivatives, metabolites...

Details Use of 17-ketosteroid compounds and derivatives, metabolites... Use of 17-ketosteroid compounds and derivatives, metabolites...

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61K 31/565 (2006.01) C07J 1/00 (2006.01) C07J 3/00 (2006.01)

Patent

CA 2356539

The invention provides the use of 17-ketosteroid compounds, as well as derivatives, metabolites and precursors of such compounds, and pharmaceutically acceptable salts of any of these compounds, collectively defined herein as the "compounds of the present invention", in the treatment of malaria, African Trypanosomiasis and American Trypanosomiasis, or to ameliorate or reduce one or more symptoms associated with a Plasmodium or Trypanosoma infection. The present invention is further directed to the use of such compounds in the treatment or prevention of one or more kind of parasites and/or one or more diseases caused by such parasites, against one or more kind of Mycoplasma and/or one or more diseases caused by such Mycoplasmas and/or against one or more of the following indications or infections: (a) hairy Leukoplakia, (b) oral candidosis, (c) mouth ulcerations- aphthous/herpetic/bacterial, (d) fungal candida, (e) human papilloma virus, (f) molluscum contagiosum, (g) squamous oral carcinoma, (h) Kaposi's sarcoma oral lesions, (i) periodontitis, (j) necrotizing gingivitis, (k) orafacial herpes zoster, and (1) rotaviruses, as well as all other indications and infections. The compounds of the present invention may also be used to ameliorate or reduce one or more symptoms associated with any infection or condition disclosed herein.

L'invention concerne l'utilisation de composés 17-cétostéroïdes, ainsi que des dérivés, des métabolites et des précurseurs desdits composés, et des sels pharmaceutiquement acceptables de l'un quelconque de ces composés (ci-après appelés collectivement "composés de l'invention") destinés à traiter le paludisme et la trypanosiomase africaine ou américaine, ou à améliorer ou réduire un ou plusieurs symptômes associés à l'infection à Plasmodium ou à Trypanosoma. L'invention concerne également l'utilisation desdits composés pour le traitement ou la prévention d'un ou plusieurs types de parasites et/ou d'une ou plusieurs maladies causées par ces parasites, contre un ou plusieurs types de Mycoplasma et/ou une ou plusieurs maladies causées par ces mycoplasmes et/ou une ou plusieurs des indications ou infections suivantes: a) la leucoplasie chevelure, b) la candidose buccale, c) les ulcérations buccales (aphteuses, herpétiques, bactériennes), d) l'infection fongique à candida, e) le papillomavirus, f) le molluscum contagiosum, g) le carcinome buccal squameux, h) les lésions buccales dues à la maladie de Kaposi, i) la parodontite, j) la gingivite nécrosante, k) le zona bucco-facial; et 1) des rétrovvirus, ainsi que d'autres indications ou infections. Les composés de l'invention peuvent être également utilisés pour améliorer ou diminuer un ou plusieurs symptômes associés à l'une quelconque des infections ou maladies ci-décrites.

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