Use of 2,5-anhydro-d-mannitol as a food intake modifier

Details Use of 2,5-anhydro-d-mannitol as a food intake modifier Use of 2,5-anhydro-d-mannitol as a food intake modifier

A - Human Necessities

61

K

167/245

A61K 31/34 (2006.01)

Patent

CA 1305422

?-49 USE OF 2,5-ANHYDRO-D-MANNITOL AS A FOOD INTAKE MODIFIER Abstract of the Invention A novel method for altering the food intake of a mammal is disclosed wherein 2,5-anhydro-D-mannitol (2,5-AM) is administered to that mammal in an amount sufficient to alter its food intake. Preferably, normal feeding and fasting periods, and most preferably diurnal feeding and fasting periods, are identified. The mammal receives an intragastric, or intraperi- toneal, or intravenous administration within two hours in advance of the onset of the feeding period to decrease food intake, or within two hours of the onset of the fasting period to increase intake. The subject mannitol is preferably administered in amounts of 50-800 mg/kg, although neither the lower limit of sufficiency nor the upper limit of activity have yet to be identified.

547515

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