Use of 2-alkoxyphenyl-substituted imidazotriazinones

Details Use of 2-alkoxyphenyl-substituted imidazotriazinones Use of 2-alkoxyphenyl-substituted imidazotriazinones

A - Human Necessities

61

K

A61K 31/53 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2454414

The invention relates to the use of known 2-phenyl substituted imidazotriazinones having short, unbranched alkyl radicals in the 9 position and cGMP-PDE-inhibiting properties for the production of medicaments to treat heart insufficiency, psoriasis, female infertility, cancer, diabetes, eye diseases such as glaucoma, disorders of stomach movement, cystic fibrosis, premature contractions, pulmonary high blood pressure, bladder diseases, prostatic hyperplasia, nitrate-induced tolerance, preeclampsia, alopecia, Parkinson's disease, pain, tinnitus or renal syndrome.

La présente invention concerne l'utilisation d'imidazotriazinones 2-phényl substituées connues comportant des groupes alkyle courts, non ramifiés en position 9 et présentant des propriétés d'inhibition de cGMP-PDE, afin de produire des médicaments permettant de traiter l'insuffisance cardiaque, le psoriasis, la stérilité féminine, le cancer, le diabète, des maladies oculaires telles que le glaucome, des troubles de la mobilité gastrique, la fibrose cystique, les contractions prématurées, l'hypertension pulmonaire, des maladies de la vessie, l'hyperplasie prostatique, la tolérance induite par le nitrate, la prééclampsie, l'alopécie, la maladie de Parkinson, la douleur, l'acouphène ou le syndrome rénal.

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