Use of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives...

Details Use of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives... Use of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives...

A - Human Necessities

61

K

A61K 31/60 (2006.01) A61K 31/192 (2006.01) A61K 31/222 (2006.01)

Patent

CA 2332863

The invention relates to the use of 2-hydroxy-4-trifluoromethylbenzoïc acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-B. The invention also relates to the utilization of 2-hydroxy-4- trifluoromethylbenzoïc acid derivatives for the preparation of medicaments to treat or prevent of pathologies associated to the activation of NF-B and/or the expression of genes which are dependent on or regulated by, at least partially, NF-B in mammals, including humans.

L'invention concerne l'utilisation de dérivés de l'acide 2-hydroxy-4-trifluorométhylbenzoïque permettant d'inhiber l'activation du facteur de transcription nucléaire NF-?B. L'invention concerne en outre l'utilisation de dérivés de l'acide 2-hydroxy-4-trifluorométhylbenzoïque permettant de préparer des médicaments pour le traitement ou la prévention de pathologies associées à l'activation du NF-?B et/ou l'expression de gènes dépendants ou régulés, au moins partiellement, par le NF-?B chez les mammifères, y compris l'homme.

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