Use of 20-hete synthesizing enzyme inhibitors as therapy for...

Details Use of 20-hete synthesizing enzyme inhibitors as therapy for... Use of 20-hete synthesizing enzyme inhibitors as therapy for...

A - Human Necessities

61

K

A61K 31/155 (2006.01) A61K 31/145 (2006.01) A61K 31/15 (2006.01) A61K 31/20 (2006.01) A61K 31/4164 (2006.01) A61K 31/4174 (2006.01) A61K 31/4192 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 25/06 (2006.01) A61P 25/28 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2427557

A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent a decrease in cerebral blood flow in the human or non-human animal. This can be obtained by treating the animal with inhibitors of CYP4A or CYP4F family of enzymes, such as HET0016, 17-ODYA (17-octadecynoic acid), DDMS (dibromododecenyl methylsulfimide), 1-ABT (1-aminobenzotriazole) and miconazole, or with an antibody to 20-HETE synthetizing enzyme or with an antisense oligo-nucleotide directed against 5' end of CYP4A1, CYP4A2, CYP4A11, CYP4F2 or CYP4F3.

L'invention concerne une méthode de traitement de maladies vasculaires cérébrales chez des animaux humains et non humains. La méthode consiste à inhiber suffisamment l'activité d'une enzyme de synthèse de 20-HETE, de manière à accroître le flux sanguin cérébral chez l'animal humain ou non humain ou à empêcher une baisse dudit flux.

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