Use of 3,4-diphenyl chromans for the manufacture of a...

A - Human Necessities – 61 – K

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A61K 31/40 (2006.01) A61K 31/35 (2006.01) A61K 31/4025 (2006.01)

Patent

CA 2241623

The present invention provides novel uses of compounds of general formula (I) wherein R1, R4, and R5 are individually hydrogen, hydroxy, halogen, trifluoro- methyl, C1-6 alkyl, C1-6 alkoxy or (tertiary amino)(C1-6 alkoxy); and R2 and R3 are individually hydrogen or C1-6 alkyl, or as a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms.

Cette invention se rapporte à de nouvelles utilisations de composés représentés par la formule générale (I), où R?1¿, R?4¿ et R?5¿ représentent séparément hydrogène, hydroxy, halogène, trifluorométhyle, C¿1-6? alkyle, C¿1-6? alkoxy ou (C¿1-6? alkoxy)(amino tertiaire); et R?2¿ et R?3¿ représentent séparément hydrogène ou C¿1-6? alkyle; ou d'un sel pharmaceutiquement acceptable de ces composés, combinés à un excipient pharmaceutiquement acceptable, dans la fabrication d'une composition pharmaceutique servant au traitement ou à la prophylaxie des symptômes ménopausiques.

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