Use of 3,4-diphenyl chromans for the manufacture of a...

A - Human Necessities – 61 – K

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A61K 31/40 (2006.01) A61K 31/35 (2006.01) A61K 31/353 (2006.01) A61K 31/4025 (2006.01)

Patent

CA 2208861

The present invention provides novel uses of compounds of general formula (I) wherein R1, R4 and R5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl, lower alkoxy or (tertiary amino)(lower alkoxy); and R2 and R3 are individually hydrogen or lower alkyl, or as a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of gynaecological disorders, including endometriosis, dysfunctional bleedings, endometrial cancer, polycystic ovarian syndrome and anovulatoric bleeding and furthermore for thinning of the endometrium.

On décrit de nouvelles utilisations de composés de formule (I) où R1, R4 et R5 représentent individuellement hydrogène, hydroxy, halogène, trifluorométhyle, alkyle inférieur, alcoxy inférieur ou (alcoxy inférieur)(amino tertiaire); et R2 et R3 représentent individuellement hydrogène ou alkyle inférieur. Ces composés, ou un de leurs sels pharmacologiquement acceptables, combinés avec un vecteur pharmacologiquement acceptable, permettent d'obtenir une composition pharmaceutique servant au traitement ou à la prophylaxie de troubles gynécologiques, y compris l'endométriose, les ménométrorragies fonctionnelles, le cancer de l'utérus, la polykistose ovarienne et les hémorragies anovulatoires, ainsi qu'à l'induction d'une hypoplasie de l'endomètre.

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